It is possible to combine the results of several small studies to produce evidence that is stronger than that available from each study alone—a statistical method known as meta-analysis. One of four such analyses, conducted in 2006, looked at 19 studies on a total of 1,084 patients.[23] It concluded that a third achieved an excellent reduction in seizure frequency and half the patients achieved a good reduction.[18]

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Let’s face it: a ketogenic diet is not the easiest diet to follow — or understand! This is why we love books that simplify the process, like Keto Made Easy: 100+ Easy Keto Dishes Made Fast to Fit Your Life. You don’t have to miss out on your favorite foods with these easy-to-follow, easy-to-make recipes from this popular food blogger duo. It also has five meal plans for different kinds of keto diets, including vegetarian. A Bible for many keto dieters, Leanne Vogel’s The Keto Diet Book: The Complete Guide to a High-Fat Diet not only boasts 125 recipes but also is a great resource chock full of information to answer your every question about this sometimes perplexing diet. We love that it has five 28-day meal plans, taking the stress out of planning every meal for weeks or even months on end. 

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Normal dietary fat contains mostly long-chain triglycerides (LCTs). Medium-chain triglycerides (MCTs) are more ketogenic than LCTs because they generate more ketones per unit of energy when metabolised. Their use allows for a diet with a lower proportion of fat and a greater proportion of protein and carbohydrate,[18] leading to more food choices and larger portion sizes.[4] The original MCT diet developed by Peter Huttenlocher in the 1970s derived 60% of its calories from MCT oil.[15] Consuming that quantity of MCT oil caused abdominal cramps, diarrhea, and vomiting in some children. A figure of 45% is regarded as a balance between achieving good ketosis and minimising gastrointestinal complaints. The classical and modified MCT ketogenic diets are equally effective and differences in tolerability are not statistically significant.[9] The MCT diet is less popular in the United States; MCT oil is more expensive than other dietary fats and is not covered by insurance companies.[18]
Sleep enough – for most people at least seven hours per night on average – and keep stress under control. Sleep deprivation and stress hormones raise blood sugar levels, slowing ketosis and weight loss a bit. Plus they might make it harder to stick to a keto diet, and resist temptations. So while handling sleep and stress will not get you into ketosis on it’s own, it’s still worth thinking about.

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Although many hypotheses have been put forward to explain how the ketogenic diet works, it remains a mystery. Disproven hypotheses include systemic acidosis (high levels of acid in the blood), electrolyte changes and hypoglycaemia (low blood glucose).[19] Although many biochemical changes are known to occur in the brain of a patient on the ketogenic diet, it is not known which of these has an anticonvulsant effect. The lack of understanding in this area is similar to the situation with many anticonvulsant drugs.[56]

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Normal dietary fat contains mostly long-chain triglycerides (LCTs). Medium-chain triglycerides (MCTs) are more ketogenic than LCTs because they generate more ketones per unit of energy when metabolised. Their use allows for a diet with a lower proportion of fat and a greater proportion of protein and carbohydrate,[18] leading to more food choices and larger portion sizes.[4] The original MCT diet developed by Peter Huttenlocher in the 1970s derived 60% of its calories from MCT oil.[15] Consuming that quantity of MCT oil caused abdominal cramps, diarrhea, and vomiting in some children. A figure of 45% is regarded as a balance between achieving good ketosis and minimising gastrointestinal complaints. The classical and modified MCT ketogenic diets are equally effective and differences in tolerability are not statistically significant.[9] The MCT diet is less popular in the United States; MCT oil is more expensive than other dietary fats and is not covered by insurance companies.[18]

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Let’s face it: a ketogenic diet is not the easiest diet to follow — or understand! This is why we love books that simplify the process, like Keto Made Easy: 100+ Easy Keto Dishes Made Fast to Fit Your Life. You don’t have to miss out on your favorite foods with these easy-to-follow, easy-to-make recipes from this popular food blogger duo. It also has five meal plans for different kinds of keto diets, including vegetarian. A Bible for many keto dieters, Leanne Vogel’s The Keto Diet Book: The Complete Guide to a High-Fat Diet not only boasts 125 recipes but also is a great resource chock full of information to answer your every question about this sometimes perplexing diet. We love that it has five 28-day meal plans, taking the stress out of planning every meal for weeks or even months on end.

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Advocates for the diet recommend that it be seriously considered after two medications have failed, as the chance of other drugs succeeding is only 10%.[9][31][32] The diet can be considered earlier for some epilepsy and genetic syndromes where it has shown particular usefulness. These include Dravet syndrome, infantile spasms, myoclonic-astatic epilepsy, and tuberous sclerosis complex.[9][33]

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